In vitro Trypanocidal Activity of Essential Oils of Some Plants against Trypanosoma evansi
Hassan Sobhy, Tarek Aboelnaga, Tahani Behour, Esam Razin, F Ayoughi, M Marzegar, M Sahari, H Naghdibadi, F Bakkali, S Averbeck, D Averbeck, M Idaomar, M Baldissera, Da Silva, A Oliveira, C Santos, R Vaucher, R Raffin, R Gomes, P Dambros, M Miletti, L Boligon, A, M Baldissera, Da Silva, A Oliveira, C Zimmermann, C Vaucher, R Santos, R Rech, V Tonin, A Giongo, J Mattos, C, S Barghash, A Darwish, Abou-Elnaga Tr, A Borges, J De Albuquerque Aires, Tmm Higino, M De Medeiros, Cit Dgf, Amdgl, Jad Lopes, Rcbq De Figueiredo, S Costa, C Cavadas, C Cavaleiro, L Salgueiro, Cu Do, M Sousa, V Da Silva, F Almeida-Souza, A Teles, P Neto, R Mondego-Oliveira, Mne Filho, N Taniwaki, A Abreu-Silva, Silva Calabrese, K Filho, Vem, A El-Badry, Al-Ali Kh, El-Badry Ya, K Gev, H Lima, I Neves, Mello, G Taveira, L Carvalho, M Carvalho, V Gomes, E Melo, Da Cunha, M, F Giordani, L Morrison, T Rowan, H De Koning, M Barrett, P Luize, T Tiuman, L Morello, P Maza, T Ueda-Nakamura, Dias Filho, B Cortez, Dag, D Mello, Jcp Nakamura, C, N Mahmoud, S Habeeb, K Abdelrahman, H Ashry, M Hassan, A Mantovani, G Vieira, W Cunha
Abstract
In this study, the antitrypanosomal action of Lavandula angustifolia Mill. (Lavender), Matricaria chamomilla L. (chamomile) and Ocimum basilicum L. (Basil) essential oils was investigated against Trypanosoma evansi. The Gas Chromatography/Mass Spectrometry (GC/MS) was used to analyze these essential oils and identifying their chemical components. The main components present in lavender oil were 1,8-cineole (88.02%) and camphor (8.09%). In chamomile oil, bisabolol oxide (43.81%), cis-α-farnesene (17.79%) and bisabolone oxide (7.71%) were found to be the most predominant components. Basil oil is principally composed of benzene, 1-methoxy-4-(2-propenyl) (52.68%), L-linalool (29.46%) and 1, 8-cineole (9.46%). In vitro results revealed that all the tested oils exhibited notable trypanocidal action and inhibited the growth of T. evansi. The minimum antitrypanosomal activity was determined by chamomile oil and the strongest was determined by lavender oil. These findings suggest that the tested essential oils could be investigated in future studies for the treatment of T. evansi.