Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons
Shihao Lin, Krishnapriya Hari, Sophie Black, Aysan Khatmi, Karim Fouad, Monica A. Gorassini, Yaqing Li, Ana M. Lucas‐Osma, Keith K. Fenrich, David J. Bennett
Abstract
Locomotor-related propriospinal neurons depolarize sensory axons throughout the spinal cord by either direct glutamatergic axoaxonic contacts or indirect innervation of GABAergic neurons that themselves form axoaxonic contacts on sensory axons. This depolarization (PAD) increases sensory transmission to motoneurons throughout the spinal cord, readying the sensorimotor system for external disturbances. The glutamate-mediated PAD is particularly adaptable, increasing with either an acute block of GABA receptors or chronic spinal cord injury, suggesting a role in motor recovery.
Topics & Concepts
NeuroscienceDepolarizationSensory systemAfferentNeurotransmissionElectrophysiologyTransmission (telecommunications)PsychologyBiologyBiophysicsComputer scienceReceptorTelecommunicationsBiochemistryNeuroscience and Neural EngineeringNeuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology Research