Construction and Aromatization of Hantzsch 1,4‐Dihydropyridines under Microwave Irradiation: A Green Approach
Majid M. Heravı, Vahideh Zadsirjan
Abstract
Abstract Hantzsch reaction, leading to the synthesis of 1,4‐dihydropyridines (1,4‐DHPs) with momentous biological activities and pharmacological properties is a well‐known MCR. In recent years, microwave irradiation (MWI) has been successfully used as the unconventional and green source of energy to promote organic transformations including Hantzsch 1,4‐dihydropyridines. Literature survey disclosed that construction of 1,4‐DHPs as well as their aromatization can be successfully performed under MWI in solution as well as in dry media. In this review, we try to underscore recent advances in the synthesis and aromatization of Hantzsch 1,4‐DHPs under MWI as green approach.
Topics & Concepts
AromatizationMicrowave irradiationChemistryDHPSCombinatorial chemistryOrganic chemistryCatalysisBiologyImmunologyPlasmodium falciparumMalariaMulticomponent Synthesis of HeterocyclesMicrowave-Assisted Synthesis and ApplicationsSynthesis and biological activity