Retinoprotective effect of donepezil in diabetic mice involves mitigation of excitotoxicity and activation of PI3K/mTOR/BCl2 pathway
Sawsan A. Zaitone, Reem Alshaman, Abdullah Alattar, Nehal M. Elsherbiny, Noha M. Abogresha, Mohamed K. El-Kherbetawy, Abdelhakeem A. Elaskary, Abdullah A. Hashish, Laila Ahmed Rashed, Eman Ahmed
Topics & Concepts
PI3K/AKT/mTOR pathwayNeuroprotectionEndocrinologyWestern blotSalineExcitotoxicityInternal medicineDonepezilStreptozotocinApoptosisCaspase 3PharmacologyGlutamate receptorMedicineChemistryDiabetes mellitusReceptorProgrammed cell deathBiochemistryGeneDementiaDiseaseRetinal Development and DisordersNeuroscience and Neuropharmacology ResearchRetinal Diseases and Treatments