LncRNAs as Potential Therapeutic Targets in Thyroid Cancer
Zeeshan Javed, Faiez Ahmed Shah, Sadegh Rajabi, Qamar Raza, Zaheer Iqbal, Mukhtar Ullah, Touqeer Ahmad, Bahare Salehi, Mehdi Sharifi‐Rad, Raffaele Pezzani, Faryal Yaqoob, Haleema Sadia, Marcello Iriti, Javad Sharifi‐Rad, William C. Cho
Abstract
Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable prediction as well as increasing overall survival rate of patients. Long non-coding RNAs (lncRNAs), have vast implications in different cancer types. Although they are not transcribed into proteins, they can act as a harness in regulating a plethora of biological functions. They have been implicated in a decisive role in gene expression via modulation of both coding and non-coding RNAs. This article discuss the multi-facet role of lncRNA in thyroid cancer biology.<br />.