ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts
Insoo Hyun, Ellen Wright Clayton, Yali Cong, Misao Fujita, Steven A. Goldman, Lori R. Hill, Nuria Monserrat, Hiromitsu Nakauchi, Roger A. Pedersen, Heather M. Rooke, Jun Takahashi, Juergen A. Knoblich
Abstract
The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryos and postnatal animals explains and summarizes their recommendations.
Topics & Concepts
BiologyInduced pluripotent stem cellStem cellGene transferHuman Induced Pluripotent Stem CellsTranslation (biology)Embryonic stem cellEngineering ethicsBiotechnologyComputational biologyCell biologyGeneticsEngineeringGeneMessenger RNAPluripotent Stem Cells ResearchBiomedical Ethics and RegulationCRISPR and Genetic Engineering