Rhodium(III)-Catalyzed Direct C–H Arylation of Various Acyclic Enamides with Arylsilanes
Xiaolan Li, Kai Sun, Wenjuan Shen, Yong Zhang, Mingzhu Lu, Xuzhong Luo, Haiqing Luo
Abstract
)-H arylation of various acyclic enamides with arylsilanes via Rh(III)-catalyzed cross-coupling reaction was illustrated. The methodology was characterized by extraordinary efficacy and stereoselectivity, a wide scope of substrates, good functional group tolerance, and the adoption of environmentally friendly arylsilanes. The utility of this present method was evidenced by the gram-scale synthesis and further elaboration of the product. In addition, Rh(III)-catalyzed C-H activation is considered to be the critical step in the reaction mechanism.
Topics & Concepts
ChemistryStereoselectivityCatalysisRhodiumCombinatorial chemistryReaction conditionsScope (computer science)Organic chemistryProgramming languageComputer scienceCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions