Gold(I)-Catalyzed Synthesis of 4<i>H</i>-Benzo[<i>d</i>][1,3]oxazines and Biological Evaluation of Activity in Breast Cancer Cells
Luis A. Segura‐Quezada, Karina R. Torres‐Carbajal, Narendra Mali, Dipak Patil, Mauricio Luna-Chagolla, Rafael Ortíz‐Alvarado, Melissa Tapia‐Juárez, Ixamail Fraire-Soto, Jorge Gustavo Araujo-Huitrado, Angélica Judith Granados‐López, Rosalinda Gutiérrez-Hernández, Claudia Araceli Reyes Estrada, Yamilé López‐Hernández, Jesús Adrián López, Luis Chacón-Garcı́a, César R. Solorio‐Alvarado
Abstract
ranking from 3.1 to 95 μM in MCF-7 and HCC1954 cells. These compounds represent potential drug candidates for BC treatment. However, additional assays are needed to elucidate their complete effect over the cellular and molecular hallmarks of cancer.
Topics & Concepts
OxazinesChemistryArylStereochemistryCombinatorial chemistryCancer cellCatalysisCell growthCycloisomerizationCancerBiochemistryOrganic chemistryBiologyGeneticsAlkylCatalytic Alkyne ReactionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods