Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to <i>FKS1</i> Mutations
Tatsuro Hirayama, Taiga Miyazaki, Makoto Sumiyoshi, Yuya Ito, Nobuyuki Ashizawa, Kazuaki Takeda, Naoki Iwanaga, Takahiro Takazono, Kazuko Yamamoto, Koichi Izumikawa, Katsunori Yanagihara, Koichi Makimura, Kazuhiro Tsukamoto, Shigeru Kohno, Hiroshi Mukae
Abstract
Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin.
Topics & Concepts
Candida aurisEchinocandinMicrobiologyEchinocandinsBiologyAntifungalGastrointestinal tractDrug resistanceCaspofunginFluconazoleBiochemistryAntifungal resistance and susceptibilityPeptidase Inhibition and AnalysisPneumocystis jirovecii pneumonia detection and treatment