Enhanced Drug Permeation into Human Keloid Tissues by Sonophoresis-Assisted Microneedling
Yating Yang, Lingling Xia, Xiaoyu Ning, Tianli Hu, Chenjie Xu, Wei Liu
Abstract
Keloids are disfiguring pathological scars that could cause pain and pruritus. The conventional treatments, such as bolus injection of drugs or surgery, are invasive and require a personal visit to clinic. Microneedle (MN) technology has great potential to offer a self-administered and minimally invasive treatment of keloids. However, drugs delivered using MNs suffer from limited penetration in keloid tissue. This study demonstrates enhanced drug penetration in human keloid scar tissue by combining MN and sonophoresis.
Topics & Concepts
KeloidMedicineScarsPenetration (warfare)DrugDermatologySurgeryPharmacologyEngineeringOperations researchDermatologic Treatments and ResearchAdvancements in Transdermal Drug DeliveryOptical Coherence Tomography Applications