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Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer

Xuemei Deng, Tian Luo, Xi Zhang, Yuehua Li, Liming Xie, Weifan Jiang, Linyi Liu, Zhen Wang

2022European Journal of Medicinal Chemistry14 citationsDOI

Topics & Concepts

TopoisomeraseChemistryDruggabilityIsoquinolineDNA damageEtoposideCytotoxicityBiochemistryTopotecanStereochemistryDocking (animal)Cancer cellIn vitroDNABiologyCancerGeneticsNursingGeneMedicineChemotherapyCancer therapeutics and mechanismsBerberine and alkaloids researchSynthesis and Biological Activity
Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer | Litcius