Triazine-Porphyrin-based aminal linked porous organic polymer as self-enhanced photo/enzyme synergistic antibacterial agent for wound healing
Zhengxuan Pan, Yiyue Fu, Cheng Peng, Xiao Lin, Shourong Zhu, Fujun Peng, Qian Liu, Baolong Zhou
Abstract
Here, a series of heteroatom-rich porous organic polymers (POPs) with aminal-linkage were facilely synthesized via Schiff base polycondensation reaction between the triazine-Porphyrin based monomer bearing eight amino groups and low cost monomer containing a single aldehyde moiety (Ferrocene, imidazole , 4-bromomethylbenzaldehyde, p-hydroxybenzaldehyde and 3,5-dimethoxybenzaldehyde). The combination of photoactive triazine-Porphyrin with redox-active Ferrocene endowed the self-enhanced photothermal, photodynamic, as well as peroxidase-like activity with the special POP (TPF-POP), which could function as a smart collaborative antimicrobial antibacterial platform. Notably, in vitro experiments verified TPF-POP could not only effectively excite the generation of reactive oxygen species (ROS) from the ambient oxygen and low levels of hydrogen peroxide (H 2 O 2 ), but also transform the light energy into local heat exerting photothermal effects, presenting an effective bacterial killing effect towards both the S. aureus and E. coli at a low concentration (200 μg/mL). In vivo animal experiments demonstrated the wound coverage of TPF-POP-treated mice with back wound infection model was significantly reduced to 9.53 % within 9 days. These results confirmed TPF-POP with concurrently photocatalytic and enzymatic activity featured broad application prospect for promoting the repairing of infected wound. The as-proposed methods are available for the low-cost preparation of POPs with specific functions.