Deoxyfluorination of Carboxylic Acids with KF and Highly Electron-Deficient Fluoroarenes
Siyu Mao, Jordan H. Kramer, Haoran Sun
Abstract
A deoxyfluorination reaction of carboxylic acids using potassium fluoride (KF) and highly electron-deficient fluoroarenes is reported here, giving acyl fluorides in moderate to excellent yield (57-92% based on NMR integration and 34-95% for isolated examples).
Topics & Concepts
ChemistryYield (engineering)FluorideCarboxylic acidPotassiumMedicinal chemistryPotassium fluorideInorganic chemistryOrganic chemistryMaterials scienceMetallurgyFluorine in Organic ChemistryChemical Synthesis and AnalysisSynthesis and Reactions of Organic Compounds