Copper-catalysed low-temperature water–gas shift reaction for selective deuteration of aryl halides
Wu Li, Ruiyang Qu, Weiping Liu, Florian Bourriquen, Stephan Bartling, Nils Rockstroh, Kathrin Junge, Matthias Beller
Abstract
water-gas shift reaction at comparably low temperature. This novel approach allows deuteration of diverse (hetero)aryl halides with good functional group tolerance, and no reduction of the aromatic rings or other easily reducible formyl and cyano groups. Multi-gram experiments show the potential of this method in organic synthesis and medicinal chemistry.
Topics & Concepts
HalideWater-gas shift reactionArylCopperChemistryInorganic chemistryCatalysisPhotochemistryOrganic chemistryAlkylChemical Reactions and IsotopesAmmonia Synthesis and Nitrogen ReductionAsymmetric Hydrogenation and Catalysis