Metallo-β-Lactamases: Structure, Function, Epidemiology, Treatment Options, and the Development Pipeline
Sara E. Boyd, David M. Livermore, David C. Hooper, William Hope
Abstract
Owing to their unique structure and function and their diversity, MBLs pose a particular challenge for drug development. They evade all recently licensed β-lactam-β-lactamase inhibitor combinations, although several stable agents and inhibitor combinations are at various stages in the development pipeline. These potential therapies, along with the epidemiology of producers and current treatment options, are the focus of this review.
Topics & Concepts
EpidemiologyPipeline (software)Computational biologyMedicineIntensive care medicineBiologyComputer scienceInternal medicineProgramming languageAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingVibrio bacteria research studies