Activating SIRT1 deacetylates NF-κB p65 to alleviate liver inflammation and fibrosis via inhibiting NLRP3 pathway in macrophages
Shuli He, Yaru Wang, Jinying Liu, Pengju Li, Xiaoying Luo, Bingyong Zhang
Abstract
Activating SIRT1 inhibits the inflammation in macrophages by down-regulating NLRP3 pathway through deacetylating NF-κB p65, which in turn inhibits the activation of HSCs to alleviate hepatic inflammation and fibrosis.
Topics & Concepts
Gene knockdownInflammationSmall interfering RNAFibrosisMacrophageChemistryNF-κBDownregulation and upregulationHepatic stellate cellCancer researchWestern blotTransfectionLiver injurySignal transductionMolecular biologyCell biologyIn vitroBiologyImmunologyPharmacologyMedicineBiochemistryEndocrinologyInternal medicineApoptosisGeneLiver Disease Diagnosis and TreatmentLiver Disease and TransplantationLiver physiology and pathology