Matrine protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via upregulation of miR-9
Jinsong Jiang, Guangji Wang
Abstract
evidence that matrine was able to protect PC12 cells against LPS-evoked damage. The neuroprotective properties of matrine may be due to its regulation of miR-9 expression as well as JNK and NF-κB pathways.
Topics & Concepts
MatrineViability assaySophora flavescensPharmacologyLipopolysaccharideOxymatrineChemistryWestern blotProinflammatory cytokineApoptosisMolecular biologyInflammationBiologyImmunologyBiochemistryGeneChromatographyBioactive natural compoundsNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms