A novel mesna-based electrochemical sensor embellished with silver nanoparticles for ultrasensitive analysis of modafinil
Noha M. Hosny, Mohamed I. Gadallah, Ibrahim A. Darwısh
Abstract
@MSN/PGE with SWV enabled the determination of MOD in its bulk form and in pharmaceutical and biological matrices at the nanomolar scale (LOD = 28.59 nM) with excellent recoveries. This study represents the first report describing an electrochemical procedure for MOD detection in human plasma. The established SWV method was also validated, and the results were consistent with ICH criteria. Finally, the presented SWV procedure provides a facile, sensitive, rapid, and cost-effective approach compared to other existing methods.
Topics & Concepts
ModafinilMesnaChemistryChromatographySilver nanoparticleNanoparticleNanotechnologyMaterials sciencePharmacologySurgeryMedicineIfosfamideChemotherapyEtoposidePharmacological Effects and AssaysElectrochemical sensors and biosensorsAdvanced biosensing and bioanalysis techniques