BATF regulates innate lymphoid cell hematopoiesis and homeostasis
Qingyang Liu, Myung H. Kim, Leon Friesen, Chang H. Kim
Abstract
deficiency causes ILC lymphopenia, leading to defective ILC responses to inflammatory cytokines and defective immunity to enteric bacterial infections. Thus, Batf plays critical roles in bone marrow hematopoiesis, peripheral homeostasis, and effector functions of ILCs.
Topics & Concepts
Innate lymphoid cellHaematopoiesisBiologyProgenitor cellTranscription factorImmunologyLymphopoiesisStem cellCell biologyProgenitorInnate immune systemBone marrowImmune systemGeneticsGeneIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionEosinophilic Esophagitis