Discovery of novel microtubule stabilizers targeting taxane binding site by applying molecular docking, molecular dynamics simulation, and anticancer activity testing
Hui Zhang, Hua-Zhao Qi, Jun Mao, Hongrui Zhang, Qing-Qing Luo, Mei‐Ling Hu, Chen Shen, Lan Ding
Topics & Concepts
HeLaTubulinMicrotubuleChemistryTaxaneMicrotubule polymerizationCell cycleDocking (animal)Cell cycle checkpointA549 cellApoptosisCancer cellCell biologyBiophysicsIn vitroBiochemistryBiologyCancerBreast cancerGeneticsNursingMedicineMicrotubule and mitosis dynamicsCancer therapeutics and mechanisms14-3-3 protein interactions