Synthesis and evaluation of sulfonamide derivatives targeting EGFR790M/L858R mutations and ALK rearrangement as anticancer agents
Longcai Cao, Han Yao, Linlin Yu, Yuanyuan Ren, Jiadai Liu, Xingshu Li, Jia Xian
Topics & Concepts
ChemistryCell cultureCytotoxicitySulfonamideApoptosisCell growthMolecular biologyBiochemistryCancer researchStereochemistryIn vitroBiologyGeneticsLung Cancer Treatments and MutationsCancer therapeutics and mechanismsPI3K/AKT/mTOR signaling in cancer