18-Residue Peptaibols Produced by the Sponge-Derived <i>Trichoderma</i> sp. GXIMD 01001
Xiao Lin, Zhenzhou Tang, Yuman Gan, Zhengyuan Li, Xiaowei Luo, Chenghai Gao, Longyan Zhao, Ling Chai, Yonghong Liu
Abstract
Seven new 18-residue peptaibols, trichorzins A–G ( 1 – 7 ), were isolated from the sponge-derived fungus Trichoderma sp. GXIMD 01001. Their structures and configurations were characterized by a comprehensive interpretation of the NMR spectroscopic data, MS/MS fragmentation, Marfey’s method, and ECD analysis. The general sequences of trichorzins A–G are as follows: Ac-Aib 1 -Ala/Ser 2 -Ala 3 -Aib/Iva 4 -Iva 5 -Gln 6 -Aib/Iva 7 -Val/ allo -Ile 8 -Aib 9 -Gly 10 -Leu 11 -Aib 12 -Pro 13 -Leu 14 -Aib 15 -Aib 16 -Gln 17 -Trpol/Pheol 18 . The obtained compounds were assessed for their potential antiproliferative and antimicrobial activities. All obtained compounds did not show potent antibacterial activity but exhibited significant cytotoxicity, with the lowest IC 50 values at 0.46–4.7 μM against four human carcinoma cell lines.