Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles
Gang‐Wei Wang, Olivia Boyd, Tom A. Young, Sophie M. Bertrand, John F. Bower
Abstract
We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I) catalysts and CO. Using this approach, a wide array of polycyclizations are achieved, including variants that involve powerful dearomatizations and medium ring formations.
Topics & Concepts
ChemistryBlueprintAtom (system on chip)Reactivity (psychology)Ring (chemistry)Range (aeronautics)NanotechnologyCombinatorial chemistryOrganic chemistryComputer scienceParallel computingEngineeringMaterials sciencePathologyMechanical engineeringComposite materialMedicineAlternative medicineCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions