Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives
Rahul Bhattacharjee, Ankit Jana, Aditya Nandi, Adrija Sinha, Arkadyuti Bhattacharjee, Sagnik Mitra, Sulagna Kar, Abhijit Dey, Sushil Kumar Singh, Rajender S. Varma, Pritam Kumar Panda, Mrutyunjay Suar, Suresh K. Verma
Abstract
Synergistic action of nanocarriers and CRISPR can be used for ablation of many genomic disorders. The enhanced delivery system is mediated by the endosomal escape mechanism. The synergistic strategizes is used for many neurodegenerative disorders as well as infection system.
Topics & Concepts
CRISPRNanocarriersGenome editingExploitCas9Duchenne muscular dystrophyNanotechnologyComputational biologyComputer scienceBioinformaticsBiologyMaterials scienceDrug deliveryGeneticsGeneComputer securityCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery