Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site
Yu-Ying Shao, Yong Yin, Baoping Lian, Jiafu Leng, Yuan‐Zheng Xia, Ling‐Yi Kong
Topics & Concepts
ChemistryTubulinColchicineCytotoxicityApoptosisCell cycleMicrotubuleMicrotubule polymerizationCell cycle checkpointCancer cellCell growthBiochemistryCell culturePaclitaxelCellCell biologyIn vitroCancerBiologyGeneticsBioactive Compounds and Antitumor AgentsSynthesis and Biological EvaluationSynthesis and biological activity