Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(<scp>ii</scp>), Co(<scp>ii</scp>) and Ni(<scp>ii</scp>) complexes – combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CL<sup>Pro</sup>
Karunganathan Sakthikumar, Bienfait Kabuyaya Isamura, Rui W. M. Krause
Abstract
Mn( ii ), Co( ii ), and Ni( ii ) morpholine and 2,2′-bipyridine complexes gave potent DNA cleavage, antimicrobial and antioxidant activity. Calculations support the results, with the Co and Ni complexes showing better anticancer efficacy than cisplatin.
Topics & Concepts
MorpholineAntioxidantChemistryAntimicrobialCisplatinCombinatorial chemistryStereochemistryMedicinal chemistryNuclear chemistryBiochemistryOrganic chemistryBiologyChemotherapyGeneticsMetal complexes synthesis and propertiesSynthesis and Biological EvaluationDNA and Nucleic Acid Chemistry