ZEB1 promotes colorectal cancer cell invasion and disease progression by enhanced LOXL2 transcription.
Fan Wang, Guiyin Sun, Chunfang Peng, Jiangyan Chen, Quan Jin, Chunrong Wu, Xiaojuan Lian, Weijun Tang, Debing Xiang
Abstract
. Immunohistochemical staining of tumor tissues indicated that elevated ZEB1/LOXL2 expression was significantly associated with lymph node metastasis and TNM stage. More importantly, elevated ZEB1/LOXL2 expression was an independent prognostic factor in CRC patients. These findings provide a molecular basis for the promotion of an invasive cancer phenotype by ZEB1-LOXL2 overexpression. Our results identify ZEB1/LOXL2 as a prognostic biomarker and potential therapeutic target against progression of CRC.
Topics & Concepts
Lysyl oxidaseCancer researchColorectal cancerTranscription factorTumor progressionBiologyMetastasisCancerCell growthCell migrationMedicineCellInternal medicineGeneExtracellular matrixCell biologyBiochemistryGeneticsMicrobial metabolism and enzyme functionMacrophage Migration Inhibitory Factor