CD27−CD38+ B cells accumulated in early HIV infection exhibit transitional profile and promote HIV disease progression
Yajing Fu, Zining Zhang, Zhijun Yang, Yongjun Jiang, Xiaoxu Han, Junjie Xu, Zhenxing Chu, Haibo Ding, Sijia He, Hong Shang
Abstract
B cells during early HIV infection tend to become rapid progressors in the chronic infection stage. In this study, we identify a peripheral transitional B cell subset that accumulates during early HIV infection and may contribute to disease progression.
Topics & Concepts
CD38PhenotypeBiologyImmunologyB cellCellHuman immunodeficiency virus (HIV)DiseaseIn vitroTranscriptomeVirologyMedicineCell biologyGeneStem cellGeneticsInternal medicineAntibodyGene expressionCD34HIV Research and TreatmentImmune Cell Function and InteractionCytomegalovirus and herpesvirus research