Transformable prodrug nanoplatform <i>via</i> tumor microenvironment modulation and immune checkpoint blockade potentiates immunogenic cell death mediated cancer immunotherapy
Weijing Yang, Jinmeng Yi, Rongrong Zhu, Yichen Guo, Kaixin Zhang, Yongjian Cao, Xinyan Li, Jinjie Zhang, Zhenzhong Zhang, Yongjuan Li, Xiaoyuan Chen
Abstract
The study offers potential in tumor eradication via exploiting an "all-in-one" smart polymeric nanoplatform.
Topics & Concepts
ChemistryTumor microenvironmentCancer researchImmunogenic cell deathCancer immunotherapyFOXP3ChemoimmunotherapyImmunotherapyCancer cellImmune systemImmune checkpointPharmacologyCancerProgrammed cell deathBiochemistryApoptosisReceptorMedicineImmunologyBlockadeInternal medicineTumor cellsNanoplatforms for cancer theranosticsImmune cells in cancerCancer Immunotherapy and Biomarkers