Concurrent suppression of Aβ aggregation and NLRP3 inflammasome activation for treating Alzheimer's disease
Tao Yang, Lei Zhang, Yicun Shang, Zhenzhu Zhu, S. Jin, Zijian Guo, Xiaoyong Wang
Abstract
Bifunctional molecule BPBA inhibits Aβ aggregation and NLRP3 inflammasome activation, thereby decreasing ROS and IL-1β in vitro and vivo ; it synergistically prevents Alzheimer's disease via alleviating Aβ neurotoxicity and reducing neuroinflammation.
Topics & Concepts
InflammasomeNeurotoxicityChemistryReactive oxygen speciesOxidative stressNeuroinflammationIn vivoCell biologyReceptorGenetically modified mouseInflammationNodTransgeneBiochemistryBiologyImmunologyToxicityGeneBiotechnologyOrganic chemistryInflammasome and immune disordersTryptophan and brain disordersAlzheimer's disease research and treatments