M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B
Yu‐Shui Ma, Ting‐Miao Wu, Chang‐Chun Ling, Fei Yu, Jie Zhang, Ping‐Sheng Cao, Li‐Peng Gu, Huiming Wang, Hong Xu, Liu Li, Zhijun Wu, Gao‐Ren Wang, Wen Li, Qinlu Lin, Ji‐Bin Liu, Da Fu
Abstract
T cells. Xenograft models confirmed that M2 macrophage-derived exosomal miR-155-5p reduced the ZC3H12B expression to upregulate IL-6, which consequently induced immune escape and tumor formation. Collectively, our findings indicated that M2 macrophage-derived exosomal miR-155-5p can potentially promote the immune escape of colon cancer by impairing ZC3H12B-mediated IL-6 stability reduction, thereby promoting the occurrence and development of colon cancer.
Topics & Concepts
MicrovesiclesExosomemicroRNAMacrophageImmune systemCancer researchGene silencingBiologyDownregulation and upregulationCancer cellCancerMacrophage polarizationImmunologyCell biologyGeneGeneticsIn vitroExtracellular vesicles in diseaseImmune cells in cancerMicroRNA in disease regulation