Discovery of a novel dual-target inhibitor of CDK12 and PARP1 that induces synthetic lethality for treatment of triple-negative breast cancer
Lan Zhang, Yongqi Zhen, Feng Lu, Zhijia Li, Yingying Lü, Guan Wang, Liang Ouyang
Topics & Concepts
Synthetic lethalityTriple-negative breast cancerPARP1Cancer researchApoptosisBreast cancerChemistryCell cycle checkpointCancerCell cyclePoly ADP ribose polymeraseDNA repairBiologyMedicineInternal medicineDNABiochemistryPolymerasePARP inhibition in cancer therapyAdvanced Breast Cancer TherapiesCancer-related Molecular Pathways