Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells
Jian Gu, Jinren Zhou, Qiuyang Chen, Xiaozhang Xu, Ji Gao, Xiangyu Li, Qing Shao, Bo Zhou, Haoming Zhou, Song Wei, Qi Wang, Yuan Liang, Ling Lü
Abstract
(Cell Reports 39, 110986; June 21, 2022) In the original version of this article that published with the June 21, 2022 issue, Figure 2A featured a duplication of the flow cytograms of FOXP3 expression in PBS and lactate-induced Tregs in the control group. The error has since been addressed, and the correct version of the figure appears both online and below. The authors apologize for any confusion that this error may have caused.Figure 2Lactate sustains the stability and function of Treg cells in an inflammatory environment (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cellsGu et al.Cell ReportsJune 21, 2022In BriefLactate is a crucial metabolite in cancer and is related to tumor prognosis, metastasis, and overall survival. Gu et al. find that lactate regulates Treg cells through lactylation of MOESIN at the Lys72 residue, which enhances TGF-β signaling in the tumor microenvironment. Full-Text PDF Open Access