A double-layer thin oral film for wet oral mucosa adhesion and efficient treatment of oral ulcers
Yujie Yan, Tiannan Liu, Xin Tian, Jiang Liu, Qianming Chen, Hang Zhao
Abstract
to delivery drugs and a hydrophobic layer to isolate the saliva for unidirectional drug delivery. The double-layer oral film with extremely thin appearance (only 0.11 mm thick) offers excellent adhesion (up to 150 min on an SD rat oral ulceration), which was also matched with its drug release time (87.47% release in 2 h). Animal experiments confirmed that the double-layer oral film carrying dexamethasone sodium phosphate achieved satisfactory efficacy in the SD rat oral ulcer model. Hence, this biologically friendly double-layer thin oral film holds great promise for clinical application in topical drug therapy for oral mucosal conditions.
Topics & Concepts
Oral mucosaMaterials scienceLayer (electronics)AdhesionThin layerMouth mucosaComposite materialMedicinePathologyOral Health Pathology and TreatmentWound Healing and TreatmentsSalivary Gland Disorders and Functions