Palladium-catalyzed dearomative Heck/[4 + 3] decarboxylative cyclization of indoles with α-oxocarboxylic acids <i>via</i> C–H activation
Liwei Zhou, Pengyang Jing, Wenbo Deng, Shuyi Guo, Yun Liang, Yuan Yang
Abstract
A palladium-catalyzed dearomative Heck/[4 + 3] decarboxylative cyclization of indoles with α-oxocarboxylic acids via C−H activation is reported, which offers an efficient avenue for assembling fused indolines containing a seven-membered ring.
Topics & Concepts
ChemistryCatalysisPalladiumDecarboxylationHeck reactionCombinatorial chemistryMedicinal chemistryIndole testOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCatalytic Alkyne Reactions