NHC and photoredox catalysis dual-catalyzed 1,4-mono-/di-fluoromethylative acylation of 1,3-enynes
Jiuli Xia, Ruiyang Ma, Lihong V. Wang, Jiaqiong Sun, Guangfan Zheng, Qian Zhang
Abstract
NHC and photocatalysis dual-catalyzed mono/difluoromethylative acylation of 1,3-enynes was realized, providing fluormethyl-substituted allenyl ketones. SO 2 might play a critical role in achieving high reactivity and selectivity.
Topics & Concepts
ChemistryAcylationCatalysisDual (grammatical number)Photoredox catalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryPhotocatalysisArtLiteratureRadical Photochemical ReactionsCatalytic Cross-Coupling ReactionsChemical Synthesis and Analysis