Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery
Tengfei Ren, Yuexi Mi, Jingjing Wei, Xiangyuan Han, Xingxiu Zhang, Qian Zhu, Tong Yue, Wenhao Gao, Xudong Niu, Cuiyan Han, Bing Wei
Abstract
Thrombotic disease has been listed as the third most fatal vascular disease in the world. After decades of development, clinical thrombolytic drugs still cannot avoid the occurrence of adverse reactions such as bleeding. A number of studies have shown that the application of various nano-functional materials in thrombus-targeted drug delivery, combined with external stimuli, such as magnetic, near-infrared light, ultrasound, etc., enrich the drugs in the thrombus site and use the properties of nano-functional materials for collaborative thrombolysis, which can effectively reduce adverse reactions such as bleeding and improve thrombolysis efficiency. In this paper, the research progress of organic nanomaterials, inorganic nanomaterials, and biomimetic nanomaterials for drug delivery is briefly reviewed.