Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t(4;14)-positive multiple myeloma
Chee Man Cheong, Krzysztof M. Mrozik, D. Hewett, E. Moberly Bell, Vasilios Panagopoulos, Jacqueline E. Noll, Jonathan D. Licht, Stan Gronthos, Andrew C.W. Zannettino, Kate Vandyke
Topics & Concepts
Gene knockdownDownregulation and upregulationCell cultureCancer researchEpithelial–mesenchymal transitionMesenchymal stem cellMultiple myelomaTwist transcription factorGene signatureBiologyIn vivoGene expressionChromosomal translocationGeneMolecular biologyCell biologyImmunologyGeneticsMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsCancer Mechanisms and Therapy