Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists
Xi Xu, Qianming Du, Ying Meng, Zhiyu Li, Hongxi Wu, Yan Li, Zhili Zhao, Raoling Ge, Xiaoyu Lu, Siqi Xue, Xijing Chen, Yong Yang, Jubo Wang, Jinlei Bian
Topics & Concepts
LNCaPEnzalutamideAndrogen receptorProstate cancerChemistryPharmacologyIn vivoTetrahydroisoquinolineCancer cellCancerCancer researchInternal medicineMedicineStereochemistryBiologyBiotechnologyProstate Cancer Treatment and ResearchProtein Degradation and InhibitorsEstrogen and related hormone effects