Litcius/Paper detail

Disease-linked mutations cause exposure of a protein quality control degron

Caroline Kampmeyer, Sven Larsen-Ledet, Morten Rose Wagnkilde, Mathias Michelsen, Henriette K. M. Iversen, Sofie V. Nielsen, Søren Lindemose, A. Caregnato, Tommer Ravid, Amelie Stein, Kaare Teilum, Kresten Lindorff‐Larsen, Rasmus Hartmann‐Petersen

2022Structure28 citationsDOI

Topics & Concepts

DegronDihydrofolate reductaseProteasomeChaperone (clinical)BiologyUbiquitinProtein degradationCell biologyMutantBiochemistryUbiquitin ligaseEnzymeGenePathologyMedicineHeat shock proteins researchEndoplasmic Reticulum Stress and DiseaseUbiquitin and proteasome pathways