Optogenetic stimulation of phosphoinositides reveals a critical role of primary cilia in eye pressure regulation
Philipp P. Prosseda, Jorge A. Alvarado, Biao Wang, Tia J. Kowal, Ke Ning, W. Daniel Stamer, Yang Hu, Yang Sun
Abstract
mice that lack functional cilia. Thus, our study is the first to use optogenetics to regulate eye pressure and demonstrate that tight regulation of phosphoinositides is critical for aqueous humor homeostasis in both normal and diseased eyes.
Topics & Concepts
Trabecular meshworkOptogeneticsStimulationGlaucomaIntraocular pressureCiliumCell biologyInositolOcular hypertensionNeuroscienceBiologyMedicineInternal medicineOphthalmologyReceptorRetinal Development and DisordersGenetic and Kidney Cyst DiseasesCellular transport and secretion