Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures
Kartika Padhan, Eirini Moysi, Alessandra Noto, Alexander Chassiakos, Khader Ghneim, Maria Maddalena Perra, Sanjana Shah, Vasilis Papaioannou, Giulia Fabozzi, David R. Ambrozak, Antigoni Poultsidi, Μαρία Ιωάννου, Craig Fenwick, Samuel Darko, Daniel C. Douek, Rafick‐Pierre Sékaly, Giuseppe Pantaleo, Richard A. Koup, Constantinos Petrovas
Abstract
Significance We characterized the heterogeneity of human TFH cells at a cellular, molecular, functional, and positional level and revealed possible mechanistic links between relevant determinants of this heterogeneity. Linking the topology with specific molecular profile and function is a key aspect in the understanding of the role of particular TFH cell subsets in the pathogenesis of relevant diseases and the delivery of optimal help to GC B cells for the development of potent neutralizing antibodies.