Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling
Risto O. Juvonen, Mira Ahinko, Elmeri M. Jokinen, Juhani Huuskonen, Hannu Raunio, Olli T. Pentikäinen
Abstract
are candidates to replace traditional substrates in measuring activity of human CYP1 enzymes.
Topics & Concepts
CoumarinCYP1A2EnzymeChemistryCytochrome P450CYP1B1Active siteSubstrate (aquarium)In silicoStereochemistryBiochemistryEnzyme kineticsDocking (animal)BiologyOrganic chemistryGeneNursingMedicineEcologyPharmacogenetics and Drug MetabolismAnalytical Chemistry and ChromatographyInnovative Microfluidic and Catalytic Techniques Innovation