Green synthesis and characterisation of novel [1,3,4]thiadiazolo/benzo[4,5]thiazolo[3,2-<i>a</i>]pyrimidines <i>via</i> multicomponent reaction using vanadium oxide loaded on fluorapatite as a robust and sustainable catalyst
Nagaraju Kerru, Lalitha Gummidi, Surya Narayana Maddila, Sandeep V. H. S. Bhaskaruni, Suresh Maddila, Sreekantha B. Jonnalagadda
Abstract
]pyrimidines. The one-pot three-component fusion reaction between chosen substrates of 1,3,4-thiadiazole-amines or 2-amino-benzothiazole, aldehydes and active methylene compounds in ethanol solvent at room temperature gave an excellent yield of products (90-97%) in a swift reaction (25-30 min). The advantages of this protocol are rapid synthesis, mild reaction conditions, green solvent, easy work-up, eco-friendliness, reusability of catalyst and no need for column chromatography.
Topics & Concepts
FluorapatiteChemistryVanadiumNuclear chemistryOxideVanadium oxideCombinatorial chemistryInorganic chemistryOrganic chemistryMineralogyApatiteMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds