A Water‐Soluble Antimony‐Rich Polyoxometalate with Broad‐Spectrum Antitumor Activities
Hui‐Ping Xiao, Ya‐Shuai Hao, Xin‐Xiong Li, Peng Xu, Mingdong Huang, Shou‐Tian Zheng
Abstract
} is reported, which contains the largest number of Sb atoms in a POM so far. The Sb-rich POM has many interesting structural features and is a rare example of a soluble and water-stable giant POM. Biomedical studies indicate that the Sb-rich POM exhibits broad-spectrum antitumor activity against various cancer cell lines by reactivating the P53-dependent apoptotic processes and disrupting the mitochondrial membrane. In addition, this Sb-rich POM was capable of suppressing the growth and metastasis of a breast cancer in vivo. This work demonstrates that Sb-rich POMs are promising candidates for the development of new anticancer drugs.
Topics & Concepts
PolyoxometalateBroad spectrumAntimonySpectrum (functional analysis)Water solubleChemistryCombinatorial chemistryInorganic chemistryBiochemistryOrganic chemistryPhysicsCatalysisQuantum mechanicsPolyoxometalates: Synthesis and ApplicationsMetal-Organic Frameworks: Synthesis and ApplicationsAdvanced Nanomaterials in Catalysis