Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice
Jianming Li, Xianyu Li, Lawrence Chan, Ruinian Hu, Tian Zheng, Haojie Li, Sijun Yang
Topics & Concepts
LipotoxicityInsulin resistanceMitophagyBiologyCell biologyAutophagyInternal medicineEndocrinologyDiabetes mellitusMedicineApoptosisBiochemistryAutophagy in Disease and TherapyImmune cells in cancerExtracellular vesicles in disease