Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL
Christian Winther Eskelund, Simon Husby, Francesco Favero, Tobias Wirenfeldt Klausen, F. Germán Rodríguez-González, Arne Kolstad, Lone Bredo Pedersen, Riikka Räty, Christian H. Geisler, Mats Jerkeman, Joachim Weischenfeldt, Kirsten Grønbæk
Abstract
Eskelund et al examined clonal hematopoiesis (CH) in a cohort of patients with mantle cell lymphoma (MCL) treated with first-line chemotherapy and autologous stem cell transplantation. In young, good-risk MCL patients, CH after first-line therapy arises almost entirely from preexisting clones, stabilizes after a period of expansion posttransplantation, and does not negatively impact survival.
Topics & Concepts
Mantle cell lymphomaChemotherapyHaematopoiesisTransplantationLymphomaHematopoietic stem cell transplantationStem cellOncologyMedicineInternal medicineChemotherapy regimenCancer researchImmunologyBiologyGeneticsAcute Myeloid Leukemia ResearchLymphoma Diagnosis and TreatmentChronic Myeloid Leukemia Treatments