Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation
Haonan Li, Qiang Luo, Hu Zhang, Xuelei Ma, Zhongwei Gu, Qiyong Gong, Kui Luo
Abstract
vaccination, promoting immunogenic cell death, overcoming radiation resistance, reversing immunosuppression, as well as pre-stratifying patients and assessing therapeutic response or therapy-induced toxicity. Overall, this review aims to provide a comprehensive landscape of nanomedicine-assisted radio-immunotherapy. The underlying working principles and the corresponding design strategies for these nanomedicines are elaborated by following the concept of "from bench to clinic". Their state-of-the-art applications, concerns over their clinical translation, along with perspectives are covered.
Topics & Concepts
NanomedicineImmunotherapyMechanism (biology)CancerMedicineCancer immunotherapyTranslation (biology)Computer scienceNanotechnologyInternal medicineChemistryMaterials sciencePhysicsNanoparticleGeneBiochemistryMessenger RNAQuantum mechanicsNanoplatforms for cancer theranosticsRadiation Therapy and DosimetryRadiopharmaceutical Chemistry and Applications