Rapid One-Pot Multicomponent Dioxane-HCl Complex Catalyzed Solvent-Free Synthesis of 3,4-Dihydropyrimidine-2-One Derivatives
Tukaram S. Choudhare, Devendra S. Wagare, Vijay T. Kadam, Ajit A. Kharpe, Prashant D. Netankar
Abstract
A simple and efficient one-pot multicomponent solvent-free protocol developed for the synthesis of 3,4-dihydropyrimidine-2-one derivatives from the reaction of various aromatic aldehyde, ethyl acetoacetate, urea, and dioxane-HCl as a catalyst. The main advantages of this protocol are solvent-free, atom economy, inexpensive, excellent product yield, and use of Dioxane-HCl complex as a catalyst.
Topics & Concepts
ChemistryCatalysisAldehydeEthyl acetoacetateYield (engineering)Atom economySolventOrganic chemistryUreaBiginelli reactionCombinatorial chemistryMaterials scienceMetallurgyMulticomponent Synthesis of HeterocyclesSynthesis and biological activityQuinazolinone synthesis and applications