Pyocyanin Isolated from Pseudomonas aeruginosa: Characterization, Biological Activity and Its Role in Cancer and Neurodegenerative Diseases
Merve Tunca Koyun, Seda Şirin, Sinem Aslan Erdem, Belma Aslım
Abstract
HIGHLIGHTS The maximum production of the pyocyanin was found to occur in MFDM and with shaking. UV-VIS spectroscopy, GC-MS, and FT-IR analyses showed the presence of pyocyanin. Pyocyanin had no cytotoxic impact on L929 cells (except 50-100 μM concentrations). Pyocyanin had an antiproliferative impact on SK-MEL-30 cells. Pyocyanin had in vitro and cellular AChE inhibitory and antioxidant properties. The use of the pyocyanin as a neuroprotective agent or an anticancer agent is advised.
Topics & Concepts
PyocyaninPseudomonas aeruginosaAntioxidantNeuroprotectionChemistryMicrobiologyBiologyBiochemistryPharmacologyBacteriaVirulenceGeneGeneticsQuorum sensingPhytochemistry and Bioactivity StudiesCholinesterase and Neurodegenerative DiseasesMicrobial Natural Products and Biosynthesis